Georgia Esoteric and Molecular Lab, LLC

 

Factor II

Test Ordering Code: 1062

CPT Codes: 83891, 83896 x 2, 83898, 83903

Turnaround Time:

5 - 7 business days

Specimen:

Whole blood anticoagulated with EDTA or citrate, 1mL minimum. Store specimens at 4° C and ship at room temperature

Clinical Significance:

A mutation in the factor II (prothrombin) gene (G20210A) has been found to be associated with thrombosis and is the second most common genetic cause of thrombosis. Patients heterozygous for this mutation have an increased risk of thrombotic disorders. The overall frequency of the mutant allele is approximately 1-6% in Caucasian populations, but rare in others. If this allele is co-inherited with the with the Factor V Leiden mutation, the severity of thrombotic problems may be more severe and the age of onset may be earlier.

Indications for Testing:

History of recurrent venous thromboembolism (VTE)

First VTE at younger than 50 years of age

First Unprovoked VTE at any age

First VTE at an unusual anatomic site: (cerebral, mesenteric, portal, or hepatic veins)

First VTE related to pregnancy, the puerperium, or oral contraceptive use

Women with unexplained preganancy loss

First VTE at any age in patients with first-degree family members with VTE

Methodology:

Real - Time PCR

Reference Interval:

Negative: The patient is negative for Factor II, G20210A allele.

Heterozygous: The patient is heterozygous for Factor II, G20210A allele.

Homozygous: The patient is homozygous for Factor II, G20210A allele.

 

References:

McGlennenRC, Key NS . Clinical andlaboratory management of the prothrombin G20210A mutation. Arch Pathol Lab Med. 2002;126(11):1319-25.